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Antimicrobial Agents and Chemotherapy, October 2000, p. 2853-2854, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Anti-Candida Activity of a New Platinum Derivative

T. Watanabe,1 M. Takano,1 A. Ogasawara,1 T. Mikami,1 T. Kobayashi,2 M. Watabe,2 and T. Matsumoto1,*

Department of Microbiology, Tohoku Pharmaceutical University, Sendai 981-8558,1 and General Education Department, Kogakuin University, Hachioji, Tokyo 192-0015,2 Japan

Received 3 March 2000/Returned for modification 30 March 2000/Accepted 28 June 2000

A new platinum derivative of the form H[Pt(IV)(Hdigly)Cl2(OH)2] (Hdigly==glycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV)(Hdigly)Cl2(OH)2] on mammalian cells was 10-fold lower than that of cis-diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.

* Corresponding author. Mailing address: Department of Microbiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. Phone: (81 22) 234 4181. Fax: (81 22) 275 2013. E-mail: tmatsu{at}tohoku-pharm.ac.jp.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2853-2854, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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