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Antimicrobial Agents and Chemotherapy, October 2000, p. 2855-2857, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Excretion of beta -Lactam Antibiotics in Sweat---a Neglected Mechanism for Development of Antibiotic Resistance?

Niels Høiby,dagger ,* Charlotte Pers,dagger Helle Krogh Johansen,dagger Hanne Hansen,dagger and The Copenhagen Study Group on Antibiotics in SweatDagger

Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark

Received 13 January 2000/Returned for modification 13 April 2000/Accepted 1 July 2000

The concentrations of beta -lactam antibiotics after standard doses were measured in blood and apocrine (axilla) and eccrine (forearm) sweat from six adult healthy persons. All persons had ceftazidime (axilla, 28.4 µg/ml; forearm, 11 µg/ml) and ceftriaxone (axilla, 8.9 µg/ml; forearm, 2.5 µg/ml) in sweat, and one person had cefuroxime in sweat (axilla, 7.8 µg/ml) (all data are mean peaks). Three persons had benzylpenicillin (axilla, 2.6 to 0.1 µg/ml) and one had phenoxymethylpenicillin (axilla, 0.4 µg/ml) in sweat. Excretion of beta -lactam antibiotics in the sweat may explain why staphylococci so rapidly become resistant to these drugs.

* Corresponding author. Mailing address: Department of Clinical Microbiology 9301, Rigshospitalet, Juliane Maries Vej 22, DK-2100 Copenhagen Ø, Denmark. Phone: (45)35457788. Fax: (45)35456412. E-mail: hoiby{at}inet.uni2.dk.

dagger Member of the Copenhagen Study Group on Antibiotics in Sweat.

Dagger Other members of the study group are Leif P. Andersen, Jette Bangsborg, Mads Bennedsen, Niels H. Riewerts Eriksen, Susanne Gjedde, Jens Otto Jarløv, Michael Kemp, Anne Kjerulf, Claus Moser, Annette Nørgaard, and Jørgen Prag.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2855-2857, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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