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Antimicrobial Agents and Chemotherapy, October 2000, p. 2869-2872, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effect of Subinhibitory Concentrations of Macrolides on Expression of Flagellin in Pseudomonas aeruginosa and Proteus mirabilis

Kumiko Kawamura-Sato,1,2 Yoshitsugu Iinuma,2 Tadao Hasegawa,1 Toshinobu Horii,1 Takafumi Yamashino,1 and Michio Ohta1,*

Department of Bacteriology,1 and Department of Clinical Laboratory Medicine,2 Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan

Received 14 January 2000/Returned for modification 16 May 2000/Accepted 10 July 2000

In the present study we showed by molecular analysis that the inhibition of motility by macrolides in Proteus mirabilis and Pseudomonas aeruginosa was well correlated with the loss of the expression of flagellin. Erythromycin, clarithromycin, and azithromycin at subinhibitory concentrations (sub-MICs) suppressed the expression of flagellin dose dependently. Azithromycin had the strongest inhibitory effect on the expression of P. aeruginosa flagellin, whereas 16-membered rokitamycin had only a weak inhibitory effect. These results indicate the potential effectiveness of sub-MICs of erythromycin, clarithromycin, and azithromycin for the treatment of patients with P. mirabilis and P. aeruginosa infections.

* Corresponding author. Mailing address: Department of Bacteriology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan. Phone: 81-52-744-2099. Fax: 81-52-744-2107. E-mail: mohta{at}tsuru.med.nagoya-u.ac.jp.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2869-2872, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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