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Antimicrobial Agents and Chemotherapy, October 2000, p. 2873-2875, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Undecylenic Acid Inhibits Morphogenesis of Candida albicans

Nealoo McLain,1 Rhoda Ascanio,2 Carol Baker,2 Robert A. Strohaver,3 and Joseph W. Dolan1,2,*

Molecular and Cellular Biology & Pathobiology Program,1 Department of Prosthodontics,3 and Department of Microbiology & Immunology,2 Medical University of South Carolina, Charleston, South Carolina 29425

Received 18 April 2000/Returned for modification 19 June 2000/Accepted 14 July 2000

Resilient liners are frequently used to treat denture stomatitis, a condition often associated with Candida albicans infections. Of 10 liners tested, 2 were found to inhibit the switch from the yeast form to hyphae and a third was found to stimulate this switch. The inhibitor was determined to be undecylenic acid.

* Corresponding author. Mailing address: Dept. of Microbiology & Immunology, 173 Ashley Ave., P.O. Box 250504, Medical University of South Carolina, Charleston, SC 29425. Phone: (843) 792-1904. Fax: (843) 792-2464. E-mail: dolanjw{at}musc.edu.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2873-2875, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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