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Antimicrobial Agents and Chemotherapy, October 2000, p. 2891-2894, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

[1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha

W. R. Waters,1,* B. Frydman,2 L. J. Marton,2,3 A. Valasinas,2 V. K. Reddy,2 J. A. Harp,4 M. J. Wannemuehler,5 and N. Yarlett6

Bacterial Diseases of Livestock Unit1 and Periparturient Diseases of Cattle Unit,4 National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010; SLIL Biomedical Corporation2 and Departments of Pathology, Laboratory Medicine, and Oncology, University of Wisconsin Medical School,3 Madison, Wisconsin 53711; Veterinary Medical Research Institute, Iowa State University, Ames, Iowa 500115; and Haskins Laboratories, Pace University, New York, New York 100386

Received 2 May 2000/Returned for modification 15 June 2000/Accepted 6 July 2000

Cryptosporidium parvum infection of T-cell receptor alpha (TCR-alpha )-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-alpha -deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.

* Corresponding author. Mailing address: Bacterial Diseases of Livestock Unit, National Animal Disease Center, U.S. Department of Agriculture, Agricultural Research Service, Ames, IA 50010-0070. Phone: (515) 663-7756. Fax: (515) 663-7482. E-mail: rwaters{at}nadc.ars.usda.gov.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2891-2894, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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