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Antimicrobial Agents and Chemotherapy, October 2000, p. 2903-2904, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Bioavailability of Praziquantel Increases with Concomitant Administration of Food

Nelly Castro,1,2 Roberto Medina,2 Julio Sotelo,1,2 and Helgi Jung1,2,*

Instituto Nacional de Neurologia y Neurocirugia1 and Universidad Nacional Autonoma de Mexico,2 Mexico City, Mexico

Received 12 May 1999/Returned for modification 16 October 1999/Accepted 10 June 2000

In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.

* Corresponding author. Mailing address: Instituto Nacional de Neurologia y Neurocirugia, Insurgentes Sur 3877, 14269 Mexico City, Mexico. Phone and fax: 52-5-424-08-08. E-mail: Helgi{at}Servidol.Unam.mx.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2903-2904, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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  • Castro, N., Jung, H., Medina, R., Gonzalez-Esquivel, D., Lopez, M., Sotelo, J. (2002). Interaction between Grapefruit Juice and Praziquantel in Humans. Antimicrob. Agents Chemother. 46: 1614-1616 [Abstract] [Full Text]  
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