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Antimicrobial Agents and Chemotherapy, October 2000, p. 2905-2907, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The EmrR Protein Represses the Escherichia coli emrRAB Multidrug Resistance Operon by Directly Binding to Its Promoter Region

A. Xiong, A. Gottman, C. Park, M. Baetens, S. Pandza, and A. Matin*

Department of Microbiology and Immunology, Stanford University School of Medicine, Sherman Fairchild D317, Stanford, California 94305

Received 27 April 2000/Returned for modification 13 June 2000/Accepted 26 June 2000

EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Stanford University School of Medicine, Sherman Fairchild D317, Stanford, CA 94305. Phone: (650) 725-4745. Fax: (650) 725-6757. E-mail: a.matin{at}forsynthe.stanford.edu.

Antimicrobial Agents and Chemotherapy, October 2000, p. 2905-2907, Vol. 44, No. 10
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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