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Antimicrobial Agents and Chemotherapy, November 2000, p. 3163-3166, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

Alexander O'Neill,1 Brunello Oliva,2 Christopher Storey,1 Anthony Hoyle,1 Colin Fishwick,3 and Ian Chopra1,*

Antimicrobial Research Centre and Division of Microbiology1 and Antimicrobial Research Centre and School of Chemistry,3 University of Leeds, Leeds LS2 9JT, United Kingdom, and Department of Experimental Medicine, University of L'Aquila, Coppito-67100, L'Aquila, Italy2

Received 20 March 2000/Returned for modification 21 June 2000/Accepted 2 August 2000

A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta -subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.

* Corresponding author. Mailing address: Antimicrobial Research Centre and Division of Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 233 5604. Fax: 44 113 233 5638. E-mail: i.chopra{at}leeds.ac.uk.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3163-3166, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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