This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khan, A. A.
Right arrow Articles by Remington, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khan, A. A.
Right arrow Articles by Remington, J. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2000, p. 3169-3173, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Protection against Lipopolysaccharide-Induced Death by Fluoroquinolones

Anis A. Khan,1,2 Teri R. Slifer,1 Fausto G. Araujo,1 Yasuhiro Suzuki,1,2 and Jack S. Remington1,2,*

Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301,1 and Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California 943052

Received 1 February 2000/Returned for modification 15 May 2000/Accepted 5 August 2000

Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100 mg/kg), ciprofloxacin (250 mg/kg), and tosufloxacin (100 mg/kg) protected 75% (P = 0.0001), 25% (P = 0.002), and 50% (P = 0.002), respectively, of mice against death. The fluoroquinolones significantly reduced serum levels of interleukin-6 and tumor necrosis factor alpha in LPS-treated mice. The protective effects of fluoroquinolones in LPS-induced shock in mice may also occur in humans.

* Corresponding author. Mailing address: Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Ames Bldg., 795 El Camino Real, Palo Alto, CA 94301. Phone: (650) 853-6061. Fax: (650) 329-9853.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3169-3173, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Shaw, P. J., Hopfensperger, M. J., Ganey, P. E., Roth, R. A. (2007). Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha. Toxicol Sci 100: 259-266 [Abstract] [Full Text]  
  • Shalit, I., Halperin, D., Haite, D., Levitov, A., Romano, J., Osherov, N., Fabian, I. (2006). Anti-inflammatory effects of moxifloxacin on IL-8, IL-1{beta} and TNF-{alpha} secretion and NF{kappa}B and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus. J Antimicrob Chemother 57: 230-235 [Abstract] [Full Text]  
  • Gogos, C. A., Skoutelis, A., Lekkou, A., Drosou, E., Starakis, I., Marangos, M. N., Bassaris, H. P. (2004). Comparative Effects of Ciprofloxacin and Ceftazidime on Cytokine Production in Patients with Severe Sepsis Caused by Gram-Negative Bacteria. Antimicrob. Agents Chemother. 48: 2793-2798 [Abstract] [Full Text]  
  • Matsumoto, T., Nieuwenhuis, E. E.S., Cisneros, R. L., Ruiz-Perez, B., Yamaguchi, K., Blumberg, R. S., Onderdonk, A. B. (2004). Protective effect of ethyl-3-(3-dimethyl aminopropyl)urea dihydrochloride (EDU) against LPS-induced death in mice. J Med Microbiol 53: 97-102 [Abstract] [Full Text]  
  • Eriksson, E., Forsgren, A., Riesbeck, K. (2003). Several gene programs are induced in ciprofloxacin-treated human lymphocytes as revealed by microarray analysis. J. Leukoc. Biol. 74: 456-463 [Abstract] [Full Text]  
  • Nakano, T., Hiramatsu, K., Kishi, K., Hirata, N., Kadota, J.-i., Nasu, M. (2003). Clindamycin Modulates Inflammatory-Cytokine Induction in Lipopolysaccharide-Stimulated Mouse Peritoneal Macrophages. Antimicrob. Agents Chemother. 47: 363-367 [Abstract] [Full Text]  
  • Araujo, F. G., Slifer, T. L., Remington, J. S. (2002). Inhibition of Secretion of Interleukin-1{alpha} and Tumor Necrosis Factor Alpha by the Ketolide Antibiotic Telithromycin. Antimicrob. Agents Chemother. 46: 3327-3330 [Abstract] [Full Text]  
  • Purswani, M. U., Eckert, S. J., Arora, H. K., Noel, G. J. (2002). Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model. J Antimicrob Chemother 50: 51-58 [Abstract] [Full Text]  
  • Lindner, B., Wiese, A., Brandenburg, K., Seydel, U., Dalhoff, A. (2002). Lack of Interaction of Fluoroquinolones with Lipopolysaccharides. Antimicrob. Agents Chemother. 46: 1568-1570 [Abstract] [Full Text]  
  • Nau, R., Eiffert, H. (2002). Modulation of Release of Proinflammatory Bacterial Compounds by Antibacterials: Potential Impact on Course of Inflammation and Outcome in Sepsis and Meningitis. Clin. Microbiol. Rev. 15: 95-110 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»