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Antimicrobial Agents and Chemotherapy, November 2000, p. 3184-3185, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antimicrobial Resistance of Neisseria gonorrhoeae and Emerging Ciprofloxacin Resistance in The Netherlands, 1991 to 1998

Albert J. de Neeling,1,* Marga van Santen-Verheuvel,1 Joke Spaargaren,2 and Rob J. L. Willems1

Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven,1 and Department of Public Health, Municipal Health Service of Amsterdam, 1018 WT Amsterdam,2 The Netherlands

Received 2 June 2000/Returned for modification 16 July 2000/Accepted 8 August 2000

Surveillance of antibiotic resistance in Neisseria gonorrhoeae showed a decrease in the percentage of beta -lactamase-producing isolates but an increase in intermediately penicillin-resistant strains and strains resistant to a high level of tetracycline. MICs for the ciprofloxacin-resistant isolates that emerged increased, and these isolates had mutations in gyrA and parC similar to those observed in the Far East.

* Corresponding author. Mailing address: Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Phone: 31 30 2742729. Fax: 31 30 2744449. E-mail: Han.de.Neeling{at}rivm.nl.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3184-3185, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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