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Antimicrobial Agents and Chemotherapy, November 2000, p. 3193-3195, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Intracellular Penetration and Activity of Gemifloxacin in Human Polymorphonuclear Leukocytes

Isabel García, Alvaro Pascual,* Sofía Ballesta, Providencia Joyanes, and Evelio J. Perea

Department of Microbiology, School of Medicine, University of Seville, Seville 41009, Spain

Received 20 April 2000/Returned for modification 28 June 2000/Accepted 16 August 2000

The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo 914, Seville 41080, Spain. Phone: 34 5 4557448. Fax: 34 5 4377413. E-mail: atomas{at}cica.es.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3193-3195, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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