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Antimicrobial Agents and Chemotherapy, November 2000, p. 3199-3202, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effect of a Cellulose Acetate Phthalate Topical Cream on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys

Kelledy H. Manson,1 Michael S. Wyand,1,* Christopher Miller,2 and A. Robert Neurath3

Primedica Corporation, Worcester, Massachusetts,1 University of California Davis, Davis, California,2 and The Lindsley F. Kimball Research Institute of the New York Blood Center, New York, New York3

Received 1 December 1999/Returned for modification 9 March 2000/Accepted 28 July 2000

Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.

* Corresponding author. Mailing address: Commonwealth Life Sciences, P.O. Box 473, Stow, MA 01608. Phone: (978) 697-5486. Fax: (978) 897-4161. E-mail: mswyand{at}aol.com.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3199-3202, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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