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Antimicrobial Agents and Chemotherapy, November 2000, p. 3203-3205, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Isolation and Characterization of Tetracycline-Resistant Clinical Isolates of Helicobacter pylori

Dong H. Kwon,1,* J. J. Kim,2 M. Lee,1 Y. Yamaoka,1 M. Kato,3 M. S. Osato,1 F. A. K. El-Zaatari,1 and David Y. Graham1

Department of Medicine, Baylor College of Medicine, and Veterans Affairs Medical Center, Houston, Texas 770301; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea2; and Department of Endoscopy, Hokkaido University School of Medicine, Sapporo, Japan3

Received 14 June 2000/Returned for modification 17 July 2000/Accepted 2 August 2000

Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 µg/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.

* Corresponding author. Mailing address: Rm. 3A-320 (111D), Veterans Affairs Medical Center, 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7276. Fax: (713) 795-4471. E-mail: dkwon{at}bcm.tmc.edu.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3203-3205, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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