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Antimicrobial Agents and Chemotherapy, November 2000, p. 3206-3209, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Thrombin-Induced Platelet Microbicidal Protein Susceptibility Phenotype Influences the Outcome of Oxacillin Prophylaxis and Therapy of Experimental Staphylococcus aureus Endocarditis

V. K. Dhawan,1,2,* A. S. Bayer,2,3 and M. R. Yeaman2,3

Division of Infectious Diseases, Charles Drew University-Martin Luther King Medical Center, Los Angeles, California 900591; UCLA School of Medicine, Los Angeles, California 900242; and Division of Adult Infectious Diseases and St. John's Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California 905093

Received 6 March 2000/Returned for modification 8 May 2000/Accepted 4 August 2000

We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.

* Corresponding author. Mailing address: Division of Infectious Diseases, King-Drew Medical Center, 12021 S. Wilmington Ave., Los Angeles, CA 90059. Phone: (310) 668-3439. Fax: (310) 763-8929. E-mail: vidhawan{at}cdrewu.edu.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3206-3209, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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