AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dhawan, V. K.
Right arrow Articles by Yeaman, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dhawan, V. K.
Right arrow Articles by Yeaman, M. R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2000, p. 3206-3209, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Thrombin-Induced Platelet Microbicidal Protein Susceptibility Phenotype Influences the Outcome of Oxacillin Prophylaxis and Therapy of Experimental Staphylococcus aureus Endocarditis

V. K. Dhawan,1,2,* A. S. Bayer,2,3 and M. R. Yeaman2,3

Division of Infectious Diseases, Charles Drew University-Martin Luther King Medical Center, Los Angeles, California 900591; UCLA School of Medicine, Los Angeles, California 900242; and Division of Adult Infectious Diseases and St. John's Cardiovascular Research Center, Harbor-UCLA Medical Center, Torrance, California 905093

Received 6 March 2000/Returned for modification 8 May 2000/Accepted 4 August 2000

We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.

* Corresponding author. Mailing address: Division of Infectious Diseases, King-Drew Medical Center, 12021 S. Wilmington Ave., Los Angeles, CA 90059. Phone: (310) 668-3439. Fax: (310) 763-8929. E-mail: vidhawan{at}cdrewu.edu.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3206-3209, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2000 by the American Society for Microbiology. All rights reserved.