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Antimicrobial Agents and Chemotherapy, November 2000, p. 3206-3209, Vol. 44, No. 11
Division of Infectious Diseases, Charles Drew
University-Martin Luther King Medical Center, Los Angeles,
California 900591; UCLA School of
Medicine, Los Angeles, California 900242; and
Division of Adult Infectious Diseases and St. John's
Cardiovascular Research Center, Harbor-UCLA Medical Center,
Torrance, California 905093
Received 6 March 2000/Returned for modification 8 May 2000/Accepted 4 August 2000
We previously showed that in vitro susceptibility profiles of
Staphylococcus aureus to thrombin-induced platelet
microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin
treatment in experimental infective endocarditis. In this same model,
treatment with oxacillin (a more rapid staphylocidal agent than
vancomycin) enhanced the clearance of both tPMP-1-susceptible and
-resistant cells from vegetations. The extent of clearance was greater
for tPMP-1-susceptible cells.
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Thrombin-Induced Platelet Microbicidal Protein Susceptibility
Phenotype Influences the Outcome of Oxacillin Prophylaxis and Therapy
of Experimental Staphylococcus aureus Endocarditis
*
Corresponding author. Mailing address: Division of
Infectious Diseases, King-Drew Medical Center, 12021 S. Wilmington
Ave., Los Angeles, CA 90059. Phone: (310) 668-3439. Fax: (310)
763-8929. E-mail: vidhawan{at}cdrewu.edu.
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