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Antimicrobial Agents and Chemotherapy, November 2000, p. 3217-3219, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effect of Ceftazidime on Systemic Cytokine Concentrations in Rats

Khalid M. Alkharfy,1 John A. Kellum,2,3 Reginald F. Frye,1,4 and Gary R. Matzke1,3,4,*

Department of Pharmaceutical Sciences, School of Pharmacy,1 Departments of Anesthesiology/Critical Care Medicine2 and Medicine,3 School of Medicine, and Center for Clinical Pharmacology,4 University of Pittsburgh, Pittsburgh, Pennsylvania

Received 6 March 2000/Returned for modification 9 May 2000/Accepted 5 August 2000

The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha ) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-alpha concentrations increased significantly in nonseptic (~40 times the baseline) rats but not septic (~2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.

* Corresponding author. Mailing address: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 724 Salk Hall, Pittsburgh, PA 15216. Phone: (412) 624-8153. Fax: (412) 648-8088. E-mail: matzke+{at}pitt.edu.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3217-3219, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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