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Antimicrobial Agents and Chemotherapy, November 2000, p. 3229-3231, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolates

Franz-Josef Schmitz,1,2,* Ad C. Fluit,2 Dieter Hafner,3 Andreas Beeck,1 Mirella Perdikouli,1 Mechthild Boos,1 Sybille Scheuring,1 Jan Verhoef,2 Karl Köhrer,1 and Christof Von Eiff4

Institute for Medical Microbiology and Virology1 and Institute for Pharmacology and Clinical Pharmacology,3 Heinrich-Heine Universität Düsseldorf, Düsseldorf, and Institute of Medical Microbiology, Westfälische Wilhelms-Universität, Münster,4 Germany, and Eijkman-Winkler Institute for Medical Microbiology, University Medical Center, Utrecht, The Netherlands2

Received 3 March 2000/Returned for modification 3 May 2000/Accepted 11 August 2000

A relationship between resistance to methicillin and resistance to fluoroquinolones, rifampin, and mupirocin has been described for Staphylococcus aureus. Differences in resistance rates may be explainable by a higher spontaneous mutation rate (MR) or a faster development of resistance (DIFF) in methicillin-resistant S. aureus (MRSA). No differences in MR, DIFF, and mutations in grlA and gyrA were detected between methicillin-susceptible S. aureus and MRSA. The higher resistance rates in MRSA are not the result of hypermutability of target genes or a faster emergence of different mutations and may be the consequence of clonal spread of multiresistant MRSA.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, Geb. 22.21, D-40225 Düsseldorf, Germany. Phone and fax: 49-2132-72040. E-mail: schmitfj{at}uni-duesseldorf.de.

Antimicrobial Agents and Chemotherapy, November 2000, p. 3229-3231, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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