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Antimicrobial Agents and Chemotherapy, November 2000, p. 3232-3234, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Updated Sequence Information and Proposed Nomenclature for blaTEM Genes and Their Promoters

V. Leflon-Guibout, B. Heym, and M.-H. Nicolas-Chanoine*

Microbiology Department, Hôpital Ambroise-Paré, Université Paris V, 92100 Boulogne-Billancourt, France

Received 23 February 2000/Returned for modification 29 June 2000/Accepted 16 August 2000

The nucleotide sequences of 59 blaTEM genes encoding inhibitor-resistant TEM enzymes showed great genetic variability and were associated with different types of promoters. These findings led us to suggest an updated blaTEM gene nomenclature based on the origin of the blaTEM gene (blaTEM-1A, blaTEM-1B, blaTEM-1C, blaTEM-1D, blaTEM-1E, and blaTEM-1F) and the promoter type.


* Corresponding author. Mailing address: Microbiology Department, Hôpital Ambroise-Paré, Université Paris V, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. Phone: 33 1 49 09 55 40. Fax: 33 1 49 09 59 21. E-mail: marie-helene.nicolas-chanoine{at}apr.ap-hop-paris.fr.


Antimicrobial Agents and Chemotherapy, November 2000, p. 3232-3234, Vol. 44, No. 11
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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