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Antimicrobial Agents and Chemotherapy, December 2000, p. 3432-3433, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antiretroviral Agents Inhibit Infection of Human Cells by Porcine Endogenous Retroviruses

S. K. Powell,1 M. E. Gates,1 G. Langford,2 M.-L. Gu,1 C. Lockey,1 Z. Long,1 and E. Otto1,*

Genetic Therapy, Inc., a Novartis Company, Gaithersburg, Maryland 20878,1 and Imutran, Ltd., a Novartis Pharma AG Company, Cambridge, CB2 2YP United Kingdom2

Received 18 April 2000/Returned for modification 22 June 2000/Accepted 25 August 2000

The efficacy of antiretroviral drugs against porcine endogenous retroviruses (PERV) that may be harbored in pig organs intended for transplantation was examined in human cells in vitro. The nucleoside analogs zidovudine and dideoxyinosine were found to effectively inhibit PERV replication.

* Corresponding author. Mailing address: Genetic Therapy, Inc., a Novartis Company, 9 West Watkins Mill Rd., Gaithersburg, MD 20878. Phone: (301) 258-4759. Fax: (301) 258-4615. E-mail: ed.otto{at}pharma.novartis.com.

Antimicrobial Agents and Chemotherapy, December 2000, p. 3432-3433, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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