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Antimicrobial Agents and Chemotherapy, December 2000, p. 3456-3460, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Structural and Topological Differences between a Glycopeptide-Intermediate Clinical Strain and Glycopeptide-Susceptible Strains of Staphylococcus aureus Revealed by Atomic Force Microscopy

Susan Boyle-Vavra,1,* Jongin Hahm,2 S. J. Sibener,2 and Robert S. Daum1

Department of Pediatrics1 and Department of Chemistry and The James Franck Institute,2 The University of Chicago, Chicago, Illinois 60637

Received 2 May 2000/Returned for modification 18 July 2000/Accepted 15 September 2000

Novel cell surface topography was revealed on cocci from a glycopeptide-intermediate Staphylococcus aureus (GISA) clinical strain by using atomic force microscopy. The GISA isolate and its revertant had two parallel circumferential surface rings. One equatorial surface ring was observed in control strains. In vancomycin-susceptible strains, additional rings were formed in the presence of vancomycin. Ring depth measurements also revealed striking differences between the GISA strain and susceptible strains grown with or without vancomycin.

* Corresponding author. Mailing address: Department of Pediatrics, The University of Chicago MC 6054, 5841 S. Maryland Ave., Chicago, IL 60637. Phone: (773) 702-6401. Fax: (773) 702-1196. E-mail: sboyleva{at}midway.uchicago.edu.

Antimicrobial Agents and Chemotherapy, December 2000, p. 3456-3460, Vol. 44, No. 12
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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