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Antimicrobial Agents and Chemotherapy, February 2000, p. 396-399, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalater

Sirke Torkkell,1 Tero Kunnari,2 Kaisa Palmu,1 Juha Hakala,2 Pekka Mäntsälä,1 and Kristiina Ylihonko1,2,*

Department of Biochemistry, University of Turku, FIN-20014 Turku,1 and Galilaeus Oy, FIN-20781 Kaarina,2 Finland

Received 19 July 1999/Returned for modification 14 October 1999/Accepted 10 November 1999

Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene snoaL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nogalamycinone, demonstrating that the single cyclase dictates the C-9 stereochemistry of anthracyclines.

* Corresponding author. Mailing address: University of Turku, Department of Biochemistry, Vatselankatu 2, FIN-20014, Finland. Phone: 358-2-3336879. Fax: 358-2-3336860. E-mail: kristiina.ylihonko{at}finabo.abo.fi.

Antimicrobial Agents and Chemotherapy, February 2000, p. 396-399, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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