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Antimicrobial Agents and Chemotherapy, February 2000, p. 418-420, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Role of the PDR Gene Network in Yeast Susceptibility to the Antifungal Antibiotic Mucidin

Dana Michalkova-Papajova, Margita Obernauerova, and Julius Subik*

Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, 842 15 Bratislava, Slovak Republic

Received 22 April 1999/Returned for modification 12 October 1999/Accepted 1 November 1999

Yeast strains disrupted in the PDR1, PDR3, or PDR5 gene, but not in SNQ2, exhibited higher sensitivity to mucidin (strobilurin A) than did the isogenic wild-type strains. Different gain-of-function mutations in the PDR1 and PDR3 genes rendered yeast mutants resistant to this antibiotic. Mucidin induced PDR5 expression, but the changes in the expression of SNQ2 were only barely detectable. The results indicate that PDR5 provides the link between transcriptional regulation by PDR1 and PDR3 and mucidin resistance of yeast.

* Corresponding author. Mailing address: Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Mlynska dolina B-2, 842 15 Bratislava, Slovak Republic. Phone: 4217 60296631. Fax: 4217 65429064. E-mail: subik{at}fns.uniba.sk.

Antimicrobial Agents and Chemotherapy, February 2000, p. 418-420, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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