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Antimicrobial Agents and Chemotherapy, February 2000, p. 470-472, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Interaction of Terbinafine with Itraconazole against Clinical Isolates of Scedosporium prolificans

Joseph Meletiadis,1 Johan W. Mouton,2 Juan L. Rodriguez-Tudela,3 Jacques F. G. M. Meis,1 and Paul E. Verweij1,*

Department of Medical Microbiology, University Hospital Nijmegen,1 and Department of Medical Microbiology, Canisius Wilhelmina Hospital,2 Nijmegen, The Netherlands, and Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain3

Received 19 July 1999/Returned for modification 25 October 1999/Accepted 10 November 1999

In order to develop new approaches for the chemotherapy of invasive infections caused by Scedosporium prolificans, the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.

Antimicrobial Agents and Chemotherapy, February 2000, p. 470-472, Vol. 44, No. 2
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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