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Antimicrobial Agents and Chemotherapy, February 2000, p. 470-472, Vol. 44, No. 2
Department of Medical Microbiology,
University Hospital Nijmegen,1 and
Department of Medical Microbiology, Canisius Wilhelmina
Hospital,2 Nijmegen, The Netherlands, and
Unidad de Micología, Centro Nacional de
Microbiología, Instituto de Salud Carlos III, Majadahonda
(Madrid), Spain3
Received 19 July 1999/Returned for modification 25 October
1999/Accepted 10 November 1999
In order to develop new approaches for the chemotherapy of invasive
infections caused by Scedosporium prolificans, the in vitro
interaction between itraconazole and terbinafine against 20 clinical
isolates was studied using a checkerboard microdilution method.
Itraconazole and terbinafine alone were inactive against most isolates,
but the combination was synergistic against 95 and 85% of isolates
after 48 and 72 h of incubation, respectively. Antagonism was not
observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
In Vitro Interaction of Terbinafine with
Itraconazole against Clinical Isolates of Scedosporium
prolificans
*
Corresponding author. Mailing address: Department of
Medical Microbiology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.azn.nl.
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