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Antimicrobial Agents and Chemotherapy, March 2000, p. 756-759, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Intravitreal, Retinal, and Central Nervous System Foscarnet Concentrations after Rapid Intravenous Administration to Rabbits

Luis F. López-Cortés,1,* R. Ruiz-Valderas,1 M. J. Lucero-Muñoz,2 E. Cordero,1 M. T. Pastor-Ramos,3 and J. Marquez4

Infectious Diseases Service,1 Department of Ophthalmology,3 and Department of Neurosurgery,4 Hospital Universitario Virgen del Rocío, and Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville,2 Seville, Spain

Received 22 March 1999/Returned for modification 16 October 1999/Accepted 29 November 1999

Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two-compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels.

* Corresponding author. Mailing address: Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot, s/n. 41013, Seville, Spain. Phone: 34-5-4248265. Fax: 34-5-4248184. E-mail: lflopez{at}cica.es.

Antimicrobial Agents and Chemotherapy, March 2000, p. 756-759, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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