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Antimicrobial Agents and Chemotherapy, March 2000, p. 760-762, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Capnocytophaga ochracea: Characterization of a Plasmid-Encoded Extended-Spectrum TEM-17 beta -Lactamase in the Phylum Flavobacter-Bacteroides

Agnes Rosenau,1,* Blandine Cattier,1 Nathalie Gousset,1 Patrick Harriau,1 Alain Philippon,2 and Roland Quentin1

Département de Microbiologie Médicale et Moléculaire, Centre Hospitalier Universitaire Bretonneau, 37044 Tours cedex,1 and Service de Bactériologie, Hôpital Cochin (Université Paris V), 75679 Paris cedex 14,2 France

Received 9 June 1999/Returned for modification 2 September 1999/Accepted 29 November 1999

A plasmid-encoded extended-spectrum TEM beta -lactamase with a pI of 5.5 was detected in a Capnocytophaga ochracea clinical isolate. The bla gene was associated with a strong TEM-2 promoter and was derived from blaTEM-1a with a single-amino-acid substitution: Glu104right-arrowLys, previously assigned to TEM-17, which is thus the first TEM beta -lactamase to be reported in the phylum Flavobacter-Bacteroides.

* Corresponding author. Mailing address: Département de Microbiologie Médicale et Moléculaire, EA2639, Centre Hospitalier Universitaire Bretonneau, 2 Bd Tonnelé, 37044 Tours cedex, France. Phone: 33 247478059. Fax: 33 247473812. E-mail: rosenau{at}med.univ-tours.fr.

Antimicrobial Agents and Chemotherapy, March 2000, p. 760-762, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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