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Antimicrobial Agents and Chemotherapy, March 2000, p. 780-782, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis

William R. Kirkpatrick,1,* Robert K. McAtee,1 Annette W. Fothergill,2 David Loebenberg,3 Michael G. Rinaldi,2,4 and Thomas F. Patterson1,4

Departments of Medicine1 and Pathology,2 The University of Texas Health Science Center at San Antonio, and Audie Murphy Division, South Texas Veterans Health Care System,4 San Antonio, Texas 78284, and Schering-Plough Research Institute, Kenilworth, New Jersey 07033-05303

Received 4 August 1999/Returned for modification 7 October 1999/Accepted 9 December 1999

SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Dr., San Antonio, TX 78284-7881. Phone: (210) 567-4823. Fax: (210) 567-3303. E-mail: KIRKPATRICK{at}UTHSCSA.EDU.

Antimicrobial Agents and Chemotherapy, March 2000, p. 780-782, Vol. 44, No. 3
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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