This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Krakauer, T. Search for Related Content PubMed PubMed Citation Articles by Krakauer, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2000, p. 1067-1069, Vol. 44, No. 4
0066-4804/00/$04.00+0

Coordinate Suppression of Superantigen-Induced Cytokine Production and T-Cell Proliferation by a Small Nonpeptidic Inhibitor of Class II Major Histocompatibility Complex and CD4 Interaction

Teresa Krakauer^*

Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011

Received 9 July 1999/Returned for modification 14 December 1999/Accepted 28 December 1999

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). TJU103, a small nonpeptidic molecule that blocks the interaction between major histocompatibility complex class II and CD4 molecules inhibited SE-stimulated T-cell proliferation (by 92%) and production of tumor necrosis factor, interleukin 1, interleukin 6, and gamma interferon (by 66, 56, 76, and 72%, respectively) by human peripheral blood mononuclear cells. These data suggest that TJU103 may be useful for mitigating the pathogenic effects of SE.

---

^* Mailing address: Department of Immunology and Molecular Biology, Bldg. 1425, USAMRIID, Fort Detrick, Frederick, MD 21702-5011. Phone: (301) 619-4733. Fax: (301) 619-2348. E-mail: teresa.krakauer{at}det.amedd.army.mil.

---

Antimicrobial Agents and Chemotherapy, April 2000, p. 1067-1069, Vol. 44, No. 4
0066-4804/00/$04.00+0