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Antimicrobial Agents and Chemotherapy, April 2000, p. 1093-1096, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Control of Staphylococcal Adhesion to Polymethylmethacrylate and Enhancement of Susceptibility to Antibiotics by Poloxamer 407

Marie-Laure Veyries,1,* Francois Faurisson,1 Marie-Laure Joly-Guillou,2 and Bernard Rouveix3

Department of Microbiology and Hygiene, Louis Mourier Hospital, Colombes,2 and INSERM EPI 9933, Bichat-Claude Bernard Hospital,1 and Department of Pharmacology, Cochin Hospital,3 Paris, France

Received 28 May 1999/Returned for modification 20 September 1999/Accepted 19 January 2000

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to antibiotic activity, suggesting that combination of P407 with antibiotics could be a promising approach to the prevention of infection of foreign material.

* Corresponding author. Mailing address: INSERM EPI 9933, Hôpital Bichat-Claude Bernard, 170, blvd. Ney, 75877 Paris Cedex 18, France. Phone: (33) 1 40 25 86 10. Fax: (33) 1 40 25 86 02. E-mail: veyries{at}bichat.inserm.fr.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1093-1096, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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