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Antimicrobial Agents and Chemotherapy, April 2000, p. 1097-1099, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Toward Antiviral Strategies That Resist Viral Escape

Drew Endydagger and John Yin*

Department of Chemical Engineering, University of Wisconsin---Madison, Madison, Wisconsin 53706-1691

Received 23 July 1999/Returned for modification 3 November 1999/Accepted 3 January 2000

We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.

* Corresponding author. Mailing address: Department of Chemical Engineering, University of Wisconsin---Madison, Madison, WI 53706-1691. Phone: (608) 265-3779. Fax: (608) 262-5434. E-mail: yin{at}engr.wisc.edu.

dagger Present address: Molecular Sciences Institute, Berkeley, CA 94704.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1097-1099, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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