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Antimicrobial Agents and Chemotherapy, April 2000, p. 1108-1111, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Postantifungal Effects of Echinocandin, Azole, and Polyene Antifungal Agents against Candida albicans and Cryptococcus neoformans

Erika J. Ernst,* Michael E. Klepser, and Michael A. Pfaller

College of Pharmacy, The University of Iowa, Department of Pathology, The University of Iowa College of Medicine, Iowa City, Iowa 52242

Received 25 August 1999/Returned for modification 22 December 1999/Accepted 11 January 2000

The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of Candida albicans and Cryptococcus neoformans. Concentrations ranging from 0.125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested against C. neoformans. Fluconazole displayed no measurable PAFE against Candida albicans or Cryptococcus neoformans, either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h against Candida spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.

* Corresponding author. Mailing address: The University of Iowa, College of Pharmacy, S428 Pharmacy Building, Iowa City, IA 52242. Phone: (319) 335-8785. Fax: (319) 353-5646. E-mail: erika-ernst{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, April 2000, p. 1108-1111, Vol. 44, No. 4
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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