This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Al-Abdely, H. M.
Right arrow Articles by Graybill, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Al-Abdely, H. M.
Right arrow Articles by Graybill, J. R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2000, p. 1159-1162, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

SCH 56592, Amphotericin B, or Itraconazole Therapy of Experimental Murine Cerebral Phaeohyphomycosis Due to Ramichloridium obovoideum ("Ramichloridium mackenziei")

Hail M. Al-Abdely,1,2,* Laura Najvar,1 Rosie Bocanegra,1 Annette Fothergill,1 David Loebenberg,3 Michael G. Rinaldi,1,2 and John R. Graybill1,2

Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and Audie Murphy Veterans Administration Hospital,2 San Antonio, Texas 78284, and Schering Plough Research Institute, Kenilworth, New Jersey 070333

Received 29 September 1999/Returned for modification 23 December 1999/Accepted 1 February 2000

Ramichloridium obovoideum ("Ramichloridium makenziei") is a rare cause of lethal cerebral phaeohyphomycosis. It has been, so far, geographically restricted to the Middle East. BALB/c mice were inoculated with two strains of R. obovoideum intracranially. Therapy with amphotericin B, itraconazole, or the investigational triazole SCH 56592 was conducted for 10 days. Half the mice were monitored for survival and half were killed for determination of the fungal load in brain tissue. Recipients of SCH 56592 had significantly prolonged survival and lower brain fungal burden, and this result was found for mice infected with both of the fungal strains tested. Itraconazole reduced the brain fungal load in mice infected with one strain but not the other, while amphotericin B had no effect on brain fungal concentrations. This study indicates a possible role of SCH 56592 in the treatment of the serious cerebral phaeohyphomycosis due to R. obovoideum.

* Corresponding author. Present address: Division of Infectious Diseases, Department of Medicine (MBC 46), King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh II 21 1, Saudi Arabia. Phone: (966) 1-442-7494. Fax: (966) 1-442-7499. E-mail: abdely{at}kfshrc.edu.sa.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1159-1162, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Badali, H., de Hoog, G. S., Curfs-Breuker, I., Meis, J. F. (2009). In vitro activities of antifungal drugs against Rhinocladiella mackenziei, an agent of fatal brain infection. J Antimicrob Chemother 0: dkp390v1-dkp390 [Full Text]  
  • Al-Abdely, H. M., Najvar, L. K., Bocanegra, R., Graybill, J. R. (2005). Antifungal Therapy of Experimental Cerebral Phaeohyphomycosis Due to Cladophialophora bantiana. Antimicrob. Agents Chemother. 49: 1701-1707 [Abstract] [Full Text]  
  • Simitsopoulou, M., Gil-Lamaignere, C., Avramidis, N., Maloukou, A., Lekkas, S., Havlova, E., Kourounaki, L., Loebenberg, D., Roilides, E. (2004). Antifungal Activities of Posaconazole and Granulocyte-Macrophage Colony-Stimulating Factor Ex Vivo and in Mice with Disseminated Infection Due to Scedosporium prolificans. Antimicrob. Agents Chemother. 48: 3801-3805 [Abstract] [Full Text]  
  • Graybill, J. R., Najvar, L. K., Johnson, E., Bocanegra, R., Loebenberg, D. (2004). Posaconazole Therapy of Disseminated Phaeohyphomycosis in a Murine Model. Antimicrob. Agents Chemother. 48: 2288-2291 [Abstract] [Full Text]  
  • Imbert, F., Jardin, M., Fernandez, C., Gantier, J. C., Dromer, F., Baron, G., Mentre, F., van Beijsterveldt, L., Singlas, E., Gimenez, F. (2003). Effect of Efflux Inhibition on Brain Uptake of Itraconazole in Mice Infected with Cryptococcus neoformans. Drug Metab. Dispos. 31: 319-325 [Abstract] [Full Text]  
  • Gonzalez, G. M., Tijerina, R., Najvar, L. K., Bocanegra, R., Rinaldi, M., Loebenberg, D., Graybill, J. R. (2002). In Vitro and In Vivo Activities of Posaconazole against Coccidioides immitis. Antimicrob. Agents Chemother. 46: 1352-1356 [Abstract] [Full Text]  
  • Petraitiene, R., Petraitis, V., Groll, A. H., Sein, T., Piscitelli, S., Candelario, M., Field-Ridley, A., Avila, N., Bacher, J., Walsh, T. J. (2001). Antifungal Activity and Pharmacokinetics of Posaconazole (SCH 56592) in Treatment and Prevention of Experimental Invasive Pulmonary Aspergillosis: Correlation with Galactomannan Antigenemia. Antimicrob. Agents Chemother. 45: 857-869 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»