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Antimicrobial Agents and Chemotherapy, May 2000, p. 1346-1348, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Glycopeptide-Resistant Enterococcus faecium BM4416 Is a VanD-Type Strain with an Impaired D-Alanine:D-Alanine Ligase

Bruno Perichon,1,* Barbara Casadewall,1 Peter Reynolds,2 and Patrice Courvalin1

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France,1 and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, CB2 1QW2

Received 30 July 1999/Returned for modification 26 November 1999/Accepted 19 January 2000

VanD-type Enterococcus faecium BM4416 was constitutively resistant to vancomycin and to teicoplanin by synthesis of peptidoglycan precursors ending in D-alanyl-D-lactate. Like E. faecium BM4339, the only VanD-type strain described so far, BM4416 produced an impaired D-alanine:D-alanine ligase. Unlike for BM4339, which had a 5-bp insertion in ddl, inactivation of the gene in BM4416 was due to insertion of IS19.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (33) (1) 45 68 83 18. Fax: (33) (1) 45 68 83 19. E-mail: brunoper{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1346-1348, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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