Geographic Distribution of a Large Mobile Element That Transfers Ampicillin and Vancomycin Resistance between Enterococcus faecium Strains

doi:10.1128/AAC.44.5.1349-1351.2000

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Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Geographic Distribution of a Large Mobile Element That Transfers Ampicillin and Vancomycin Resistance between Enterococcus faecium Strains

Jennifer Hanrahan,¹ Claudia Hoyen,² and Louis B. Rice¹^,³^,^*

Medical Service, Department of Veterans Affairs Medical Center,³ and Adult¹ and Pediatric² Infectious Diseases Divisions, Case Western Reserve University School of Medicine, Cleveland, Ohio

Received 12 July 1999/Returned for modification 30 August 1999/Accepted 27 January 2000

In several clonally unrelated VanB-type vancomycin-resistant Enterococcus faecium strains, we demonstrated a common physicalrelationship between pbp5 and Tn5382 as well as common mutationswithin pbp5. The majority of these strains transferred vancomycinand ampicillin resistance to E. faecium in vitro, suggesting thedissemination of similar transferable pbp5-vanB-containing mobileelements throughout the UnitedStates.

^* Corresponding author. Mailing address: Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone:(216) 791-3800, ext. 4801. Fax: (216) 231-3289. E-mail: louis.rice{at}med.va.gov.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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