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Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Geographic Distribution of a Large Mobile Element
That Transfers Ampicillin and Vancomycin Resistance between
Enterococcus faecium Strains
Jennifer
Hanrahan,1
Claudia
Hoyen,2 and
Louis B.
Rice1,3,*
Medical Service, Department of Veterans
Affairs Medical Center,3 and
Adult1 and
Pediatric2 Infectious Diseases
Divisions, Case Western Reserve University School of Medicine,
Cleveland, Ohio
Received 12 July 1999/Returned for modification 30 August
1999/Accepted 27 January 2000
In several clonally unrelated VanB-type vancomycin-resistant
Enterococcus faecium strains, we demonstrated a common
physical relationship between pbp5 and Tn5382
as well as common mutations within pbp5. The majority of
these strains transferred vancomycin and ampicillin resistance to
E. faecium in vitro, suggesting the dissemination of
similar transferable pbp5-vanB-containing mobile elements
throughout the United States.
*
Corresponding author. Mailing address: Medical Service
111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4801. Fax: (216) 231-3289. E-mail:
louis.rice{at}med.va.gov.
Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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