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Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Geographic Distribution of a Large Mobile Element That Transfers Ampicillin and Vancomycin Resistance between Enterococcus faecium Strains

Jennifer Hanrahan,1 Claudia Hoyen,2 and Louis B. Rice1,3,*

Medical Service, Department of Veterans Affairs Medical Center,3 and Adult1 and Pediatric2 Infectious Diseases Divisions, Case Western Reserve University School of Medicine, Cleveland, Ohio

Received 12 July 1999/Returned for modification 30 August 1999/Accepted 27 January 2000

In several clonally unrelated VanB-type vancomycin-resistant Enterococcus faecium strains, we demonstrated a common physical relationship between pbp5 and Tn5382 as well as common mutations within pbp5. The majority of these strains transferred vancomycin and ampicillin resistance to E. faecium in vitro, suggesting the dissemination of similar transferable pbp5-vanB-containing mobile elements throughout the United States.

* Corresponding author. Mailing address: Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 4801. Fax: (216) 231-3289. E-mail: louis.rice{at}med.va.gov.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1349-1351, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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