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Antimicrobial Agents and Chemotherapy, May 2000, p. 1381-1382, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activity of Telithromycin (HMR3647), a New Ketolide, against Clinical Isolates of Mycoplasma pneumoniae in Japan

Toshiyuki Yamaguchi,1,* Yoichi Hirakata,1 Koichi Izumikawa,1 Yoshitsugu Miyazaki,1 Shigefumi Maesaki,2 Kazunori Tomono,2 Yasuaki Yamada,1 Shimeru Kamihira,1 and Shigeru Kohno2

Department of Laboratory Medicine1 and the Second Department of Internal Medicine,2 Nagasaki University School of Medicine, Nagasaki 852-8501, Japan

Received 20 September 1999/Returned for modification 13 January 2000/Accepted 15 February 2000

The in vitro activity of telithromycin (HMR3647), a new ketolide, against Mycoplasma pneumoniae was determined by the broth microdilution test using 41 clinical isolates obtained in Japan, as compared with those of five macrolides (erythromycin, clarithromycin, roxithromycin, azithromycin, and josamycin), minocycline, and levofloxacin. Telithromycin was less potent than azithromycin, but it was more active than four other macrolides, minocycline, and levofloxacin; its MICs at which 50 and 90% of the isolates tested were inhibited were both 0.00097 µg/ml, justifying clinical studies to determine its efficacy for treatment of M. pneumoniae.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Phone: 81 (95)-849-7420. Fax: 81 (95)-849-7422. E-mail: toshi-ngs{at}umin.ac.jp.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1381-1382, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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