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Antimicrobial Agents and Chemotherapy, May 2000, p. 1391-1393, Vol. 44, No. 5
Unité des Rickettsies, CNRS UPRES-A
6020, Faculté de Médecine, Université de la
Méditerranée, 13385 Marseille Cedex
05,1 and Anti-Infective Research
Department, Hoechst-Marion-Roussel, 93235 Romainville,2 France
Received 7 September 1999/Returned for modification 22 December
1999/Accepted 26 January 2000
In vitro activities of telithromycin compared to those of
erythromycin against Rickettsia spp.,
Bartonella spp., Coxiella burnetii, and
Ehrlichia chaffeensis were determined. Telithromycin was
more active than erythromycin against Rickettsia,
Bartonella, and Coxiella burnetii, with MICs of
0.5 µg/ml, 0.003 to 0.015 µg/ml, and 1 µg/ml, respectively, but
was inactive against Ehrlichia chaffeensis.
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
In Vitro Activities of Telithromycin (HMR 3647)
against Rickettsia rickettsii, Rickettsia
conorii, Rickettsia africae, Rickettsia
typhi, Rickettsia prowazekii, Coxiella
burnetii, Bartonella henselae, Bartonella
quintana, Bartonella bacilliformis, and
Ehrlichia chaffeensis
*
Corresponding author. Mailing address: Unité des
Rickettsies, Faculté de Médecine, 27 Boulevard Jean Moulin,
13385 Marseille Cedex 5, France. Phone: 33 04 91 32 43 75. Fax: 33 04 91 38 77 72. E-mail:
Didier.Raoult{at}medecine.univ-mrs.fr.
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