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Antimicrobial Agents and Chemotherapy, May 2000, p. 1391-1393, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of Telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis

Jean-Marc Rolain,1 Max Maurin,1 André Bryskier,2 and Didier Raoult1,*

Unité des Rickettsies, CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05,1 and Anti-Infective Research Department, Hoechst-Marion-Roussel, 93235 Romainville,2 France

Received 7 September 1999/Returned for modification 22 December 1999/Accepted 26 January 2000

In vitro activities of telithromycin compared to those of erythromycin against Rickettsia spp., Bartonella spp., Coxiella burnetii, and Ehrlichia chaffeensis were determined. Telithromycin was more active than erythromycin against Rickettsia, Bartonella, and Coxiella burnetii, with MICs of 0.5 µg/ml, 0.003 to 0.015 µg/ml, and 1 µg/ml, respectively, but was inactive against Ehrlichia chaffeensis.

* Corresponding author. Mailing address: Unité des Rickettsies, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France. Phone: 33 04 91 32 43 75. Fax: 33 04 91 38 77 72. E-mail: Didier.Raoult{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, May 2000, p. 1391-1393, Vol. 44, No. 5
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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