Resistance to Macrolides in Streptococcus pyogenes in France in Pediatric Patients

doi:10.1128/AAC.44.6.1453-1457.2000

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Antimicrobial Agents and Chemotherapy, June 2000, p. 1453-1457, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Resistance to Macrolides in Streptococcus pyogenes in France in Pediatric Patients

Edouard Bingen,¹^,^* Frederic Fitoussi,¹ Catherine Doit,¹ Robert Cohen,² Asha Tanna,³ Robert George,³ Chawki Loukil,¹ Naima Brahimi,¹ Isabelle Le Thomas,¹ and Dominique Deforche¹

Service de Microbiologie, Hôpital Robert Debré, 75019 Paris,¹ and Service de Microbiologie, Centre Hospitalier de Créteil, 94010 Créteil,² France, and Central Public Health Laboratory, London, United Kingdom³

Received 2 September 1999/Returned for modification 26 December 1999/Accepted 3 March 2000

A total of 1,500 recent throat isolates of Streptococcus pyogenes collected between 1996 and 1999 from children throughoutFrance were tested for their susceptibility to erythromycin, azithromycin,josamycin, clindamycin, and streptogramin B. The erythromycin-resistantisolates were further studied for their genetic mechanism of resistance,by means of PCR. The clonality of these strains was also investigatedby means of serotyping and ribotyping. In all, 6.2% of the strainswere erythromycin resistant, and 3.4 and 2.8% expressed the constitutiveMLS_B and M resistance phenotypes and harbored the ermB and mefAgenes, respectively; ermTR was recovered from one isolate whichalso harbored the ermB gene. Ten serotypes and 8 ribotypes wereidentified, but we identified 17 strains by combining serotypingwith ribotyping. Among the eight ribotypes, the mefA gene wasrecovered from six clusters, one being predominant, while theermB gene was recovered from four clusters, of which two werepredominant.

^* Corresponding author. Mailing address: Service de Microbiologie, Hôpital R. Debré, 48 Bd Sérurier, 75019 Paris, France.Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1453-1457, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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