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Antimicrobial Agents and Chemotherapy, June 2000, p. 1710-1712, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparative In Vitro Activities of Clinafloxacin and Trovafloxacin against 1,000 Isolates of Bacteroides fragilis Group: Effect of the Medium on Test Results

David R. Snydman,* Nilda V. Jacobus, Laura A. McDermott, and Stacey E. Supran

Departments of Medicine and Pathology and the Division of Clinical Care Research, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts

Received 11 August 1999/Returned for modification 14 December 1999/Accepted 6 March 2000

The in vitro antibacterial activities of clinafloxacin, trovafloxacin, ciprofloxacin, and cefoxitin against 1,000 clinical isolates of Bacteroides fragilis group were compared by agar dilution in brucella blood agar (BBA) and Wilkins Chalgren agar (WCA). Significantly higher geometric mean MICs for the three quinolones and cefoxitin (P < 0.001) were obtained in BBA than in WCA. Regardless of medium, clinafloxacin was slightly more active than trovafloxacin. The activity of clinafloxacin and trovafloxacin was greater than that of cefoxitin against B. distasonis, B. ovatus, and B. thetaiotaomicron but lower against B. vulgatus. High cross resistance between trovafloxacin and clinafloxacin was observed.

* Corresponding author. Mailing address: Box 238, New England Medical Center, 750 Washington St., Boston, MA 02111. Phone: (617) 636-5788. Fax: (617) 636-8525. E-mail: dsnydman{at}lifespan.org.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1710-1712, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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