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Antimicrobial Agents and Chemotherapy, June 2000, p. 1716-1719, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of Membrane-Active Peptides Alone and in Combination with Clinically Used Antimicrobial Agents against Stenotrophomonas maltophilia

A. Giacometti,* O. Cirioni, M. S. Del Prete, F. Barchiesi, M. Fortuna, D. Drenaggi, and G. Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

Received 23 September 1999/Returned for modification 6 January 2000/Accepted 10 March 2000

The in vitro activities of buforin II, cecropin P1, and magainin II, alone and in combination with six clinically used antimicrobial agents, against 12 clinical isolates of Stenotrophomonas maltophilia were investigated. Antimicrobial activities were measured by MIC and time-kill studies. The isolates were susceptible to the peptides at concentrations in the range of 0.50 to 16 µg/ml. Synergy was observed when the peptides were combined with polymyxin E, meropenem, ceftazidime, piperacillin, and clarithromycin.

* Corresponding author. Mailing address: Clinica delle Malattie Infettive, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli, 1, I-60121 Ancona, Italy. Phone: 39-071-5963467. Fax: 39-071-5963468. E-mail: cmalinf{at}popcsi.unian.it.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1716-1719, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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