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Antimicrobial Agents and Chemotherapy, June 2000, p. 1737-1738, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Failure of Azithromycin in Treatment of Brill-Zinsser Disease

Drago Turcinov,* Ilija Kuzman, and Boris Herendic'

University Hospital for Infectious Diseases, Zagreb, Croatia

Received 12 June 1998/Returned for modification 13 March 1999/Accepted 24 March 2000

Two patients suffering from Brill-Zinsser disease were treated with azithromycin, which did not prove effective. Rickettsia prowazekii, the agent causing Brill-Zinsser disease, cannot be treated with azithromycin. Both patients had epidemiological features consistent with and a clinical course typical of the disease. The diagnosis of Brill-Zinsser disease was serologically confirmed.

* Corresponding author. Mailing address: University Hospital for Infectious Diseases, Mirogojska 8, 10 000 Zagreb, Croatia. Phone: 385 1 4603 142. Fax: 385 1 4678 235. E-mail: dturcinov{at}bfm.hr.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1737-1738, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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