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Antimicrobial Agents and Chemotherapy, June 2000, p. 1749-1753, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Postantibiotic Suppression of Growth of Erythromycin A-Susceptible and -Resistant Gram-Positive Bacteria by the Ketolides Telithromycin (HMR 3647) and HMR 3004

Wendy J. Munckhof,1,* Glenn Borlace,2 and John D. Turnidge2

Department of Infectious Diseases and Clinical Epidemiology, Monash Medical Centre, Victoria 3168,1 and Department of Microbiology and Infectious Diseases, Women's and Children's Hospital, North Adelaide, South Australia 5006,2 Australia

Received 12 May 1999/Returned for modification 16 October 1999/Accepted 15 January 2000

We investigated the in vitro postantibiotic effects (PAEs) of the ketolides telithromycin (HMR 3647) and HMR 3004 and analyzed the results using the sigmoid Emax model. Mean maximum telithromycin PAEs against erythromycin A-susceptible strains of Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae were 3.7, 8.9, and 9.7 h, respectively, while maximum PAEs for erythromycin A-resistant strains were much shorter. Mean maximum HMR 3004 PAEs were 3.2 to 4.4 h for all species.

* Corresponding author. Mailing address: Department of Infectious Disease, Infection Control and Sexual Health, Princess Alexandra Hospital, Ipswich Rd., Woolloongabba, Brisbane, Queensland 4102, Australia. Phone: 61 7 3240 2595. Fax: 61 7 3240 5540. E-mail: munckhof{at}health.qld.gov.au.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1749-1753, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ackermann, G., Rodloff, A. C. (2003). Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide. J Antimicrob Chemother 51: 497-511 [Abstract] [Full Text]  
  • Neuhauser, M. M., Prause, J. L., Danziger, L. H., Pendland, S. L. (2001). Postantibiotic Effects of ABT-773 and Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. Antimicrob. Agents Chemother. 45: 3613-3615 [Abstract] [Full Text]  
  • Munckhof, W. J., Giles, C., Turnidge, J. D. (2001). Post-antibiotic growth suppression of linezolid against Gram-positive bacteria. J Antimicrob Chemother 47: 879-883 [Abstract] [Full Text]  


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