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Antimicrobial Agents and Chemotherapy, June 2000, p. 1754-1756, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Single-Oral-Dose Azithromycin Prophylaxis against Experimental Streptococcal or Staphylococcal Aortic Valve Endocarditis

Artemis Tsitsika,1,dagger Angelos Pefanis,2,* George S. Perdikaris,1,Dagger Ismini Donta,3 Panayiotis Karayiannakos,3 and Helen Giamarellou1

Infectious Diseases Section, 4th Department of Medicine, Sismanoglion General Hospital,1 and 3rd Department of Medicine, Sotiria General Hospital,2 and Section of Experimental Surgery and Surgical Research, 2nd Department of Propedeutic Surgery, Laikon General Hospital,3 Athens University School of Medicine, Athens, Greece

Received 16 August 1999/Returned for modification 22 December 1999/Accepted 21 March 2000

Azithromycin and ampicillin protected 94 and 72% of animals challenged with Streptococcus oralis, respectively (P = 0.177), while azithromycin and vancomycin protected 59 and 94% of the methicillin-resistant Staphylococcus aureus (MRSA)-challenged animals, respectively (P = 0.018). Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effective than vancomycin.

* Corresponding author. Mailing address: 3rd Department of Medicine, Athens University School of Medicine, Sotiria General Hospital, 152 Mesogion Ave., Athens 11527, Greece. Phone: 30 1-7719975. Fax: 30 1-7778838. E-mail: gpp{at}hol.gr.

dagger Present address: 1st Department of Pediatrics, University of Athens, "Agia Sofia" Children's Hospital, Goudi, GR 11527, Greece.

Dagger Deceased 23 March 1998.

Antimicrobial Agents and Chemotherapy, June 2000, p. 1754-1756, Vol. 44, No. 6
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Carmona, I. T., Diz Dios, P., Scully, C. (2007). Efficacy of Antibiotic Prophylactic Regimens for the Prevention of Bacterial Endocarditis of Oral Origin. JDR 86: 1142-1159 [Abstract] [Full Text]  


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