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Antimicrobial Agents and Chemotherapy, July 2000, p. 1930-1935, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Prevalence of beta -Lactamases among 1,072 Clinical Strains of Proteus mirabilis: a 2-Year Survey in a French Hospital

C. Chanal,1,* R. Bonnet,1 C. De Champs,1 D. Sirot,1 R. Labia,2 and J. Sirot1

Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex,1 and UMR 175, CNRS-MNHN, 29000 Quimper,2 France

Received 27 September 1999/Returned for modification 22 February 2000/Accepted 12 April 2000

beta -Lactam resistance was studied in 1,072 consecutive P. mirabilis clinical strains isolated at the Clermont-Ferrand teaching hospital between April 1996 and March 1998. The frequency of amoxicillin resistance was 48.5%. Among the 520 amoxicillin-resistant isolates, three resistance phenotypes were detected: penicillinase (407 strains [78.3%]), extended-spectrum beta -lactamase (74 strains [14.2%]), and inhibitor resistance (39 strains [7.5%]). The penicillinase phenotype isolates were divided into three groups according to the level of resistance to beta -lactams, which was shown to be related to the strength of the promoter. The characterization of the different beta -lactamases showed that amoxicillin resistance in P. mirabilis was almost always (97%) associated with TEM or TEM-derived beta -lactamases, most of which evolved via TEM-2.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Faculté de Médecine, 28, Place Henri Dunant, 63001 Clermont-Ferrand Cedex, France. Phone: 33 (0)4 73 60 80 18. Fax: 33 (0)4 73 27 74 94. E. mail: Catherine.CHANAL{at}u-clermont1.fr.

Antimicrobial Agents and Chemotherapy, July 2000, p. 1930-1935, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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