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Antimicrobial Agents and Chemotherapy, July 2000, p. 1977-1979, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of Linezolid Alone and in Combination with Amoxicillin, Clarithromycin, and Metronidazole against Helicobacter pylori

Alexander M. Hirschl,* Petra Apfalter, Athanasios Makristathis, Manfred L. Rotter, and Margit Wimmer

Department of Clinical Microbiology, Hygiene-Institute of the University of Vienna, Vienna, Austria

Received 26 October 1999/Returned for modification 7 March 2000/Accepted 11 April 2000

Linezolid was tested against 70 strains of Helicobacter pylori by the agar dilution method. The MIC range and MICs at which 50 and 90% of strains were inhibited were 8 to 64, 16, and 32 µg/ml, respectively. With minimum and maximum fractional inhibitory concentration summation values of 0.31 and 2.50, respectively, the combination of linezolid with amoxicillin, clarithromycin, or metronidazole showed either partial synergy or indifference for the majority of strains.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Hygiene-Institute of the University of Vienna, General Hospital, Währinger Gürtel 18-20/5P, A-1090 Vienna, Austria. Phone: 43 1 40400 5154. Fax: 43 1 40400 5228. E-mail: alexander.hirschl{at}akh-wien.ac.at.

Antimicrobial Agents and Chemotherapy, July 2000, p. 1977-1979, Vol. 44, No. 7
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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