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Antimicrobial Agents and Chemotherapy, August 2000, p. 2170-2172, Vol. 44, No. 8
0066-4804/00/$04.00+0

Effects of Fluconazole and Clarithromycin on Rifabutin and 25-O-Desacetylrifabutin Pharmacokinetics

M. Kelli Jordan,1 Michael A. Polis,2 Grace Kelly,2 Prem K. Narang,3 Henry Masur,4 and Stephen C. Piscitelli1,*

Departments of Pharmacy1 and Critical Care Medicine4 and Clinical Center and Laboratory of Immunoregulation,2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, and Pharmacia and Upjohn, Kalamazoo, Michigan3

Received 4 October 1999/Returned for modification 7 February 2000/Accepted 20 April 2000

Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together with rifabutin. Patients should be monitored for adverse effects of rifabutin administered concomitantly with clarithromycin and/or fluconazole.

* Corresponding author. Mailing address: Clinical Center Pharmacy Department, National Institutes of Health, Bldg. 10, Room 1N257, Bethesda, MD 20892. Phone: (301) 496-2997. Fax: (301) 480-0691. E-mail: spisc{at}nih.gov.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2170-2172, Vol. 44, No. 8
0066-4804/00/$04.00+0


This article has been cited by other articles:

  • Finch, C. K., Chrisman, C. R., Baciewicz, A. M., Self, T. H. (2002). Rifampin and Rifabutin Drug Interactions: An Update. Arch Intern Med 162: 985-992 [Abstract] [Full Text]  


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