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Antimicrobial Agents and Chemotherapy, August 2000, p. 2190-2192, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Reversion of Amphotericin B Resistance in Leishmania donovani by Poloxamer 188

S. Espuelas,1 P. Legrand,2 P. M. Loiseau,3 C. Bories,3 G. Barratt,2 and J. M. Irache1,*

Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, 31080 Pamplona, Spain,1 and UMR 86, Faculté de Pharmacie, Université Paris-Sud,2 and Biologie et Contrôle des Organismes Parasites, UPRES-EA 398, Faculté de Pharmacie, Université de Paris-Sud,3 92296 Châtenay-Malabry, France

Received 3 November 1999/Returned for modification 23 December 1999/Accepted 1 May 2000

A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.

* Corresponding author. Mailing address: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, 31080 Pamplona, Spain. Phone: 948 425600. Fax: 948 425649. E-mail: jmirache{at}unav.es.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2190-2192, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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