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Antimicrobial Agents and Chemotherapy, August 2000, p. 2193-2196, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates from Pediatric Patients in Singapore

Shirlena Wee-Ling Soh,1,2 Chit Laa Poh,2,* and Raymond V. Tzer Pin Lin1

Clinical Microbiology Laboratory, KK Women's and Children's Hospital,1 and Department of Microbiology, Faculty of Medicine, National University of Singapore,2 Singapore

Received 30 December 1999/Returned for modification 19 April 2000/Accepted 2 May 2000

One hundred eighty Streptococcus pneumoniae strains isolated from children at a pediatric hospital in Singapore from 1997 to 1999 were serotyped and their antimicrobial susceptibility patterns were determined. Sixty-three percent of the isolates were resistant to penicillin. Significantly large numbers of the strains investigated were resistant to trimethoprim-sulfamethoxazole (87.8%), tetracycline (71.7%), erythromycin (67.8%), and chloramphenicol (40%). Penicillin and multidrug resistance was mostly associated with the frequently isolated S. pneumoniae isolates of serotypes (serotypes 19F, 23F, 6B, and 14). Isolates of serotype 19F, the serotype most commonly encountered in Singapore (41.1%), had the highest prevalence of penicillin (78.4%) and multidrug resistance (94.6%). Most of the invasive S. pneumoniae isolates (8 of 17; 47.1%) were of serotype 14.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260. Phone: (65)8743674. Fax: (65)7766872. E-mail: micpohcl{at}nus.edu.sg.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2193-2196, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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