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Antimicrobial Agents and Chemotherapy, August 2000, p. 2197-2200, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Fluoroquinolone Resistance Associated with Target Mutations and Active Efflux in Oropharyngeal Colonizing Isolates of Viridans Group Streptococci

François Guerin,1,2 Emmanuelle Varon,2 Annie Buu Hoï,1 Laurent Gutmann,1,2,* and Isabelle Podglajen1,2

Service de Microbiologie, Hôpital Broussais, 75674 Paris Cedex 14,1 and L. R. M. A., Université Paris VI, 75270 Paris Cedex 06,2 France

Received 16 November 1999/Returned for modification 5 March 2000/Accepted 12 May 2000

Oropharyngeal samples from 60 hospitalized patients (30 fluoroquinolone [FQ]-treated and 30 non-FQ-treated patients) and 30 untreated nonhospitalized healthy control subjects yielded 20 isolates of viridans group streptococci with reduced susceptibility to FQ, mostly from the hospitalized patients. An efflux phenotype was commonly encountered, expressed either alone or with topoisomerase mutations. Interspecies transfer of the efflux phenotype was demonstrated via transformation of Streptococcus pneumoniae R6 with DNA from S. mitis and S. oralis.

* Corresponding author. Mailing address: L. R. M. A., Université Paris VI, 15, rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. Phone: 33-1-42-34-68-63. Fax: 33-1-43-25-68-12. E-mail: gutmann{at}ccr.jussieu.fr.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2197-2200, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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