Previous Article | Next Article 
Antimicrobial Agents and Chemotherapy, August 2000, p. 2197-2200, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Fluoroquinolone Resistance Associated with Target Mutations and
Active Efflux in Oropharyngeal Colonizing Isolates of Viridans
Group Streptococci
François
Guerin,1,2
Emmanuelle
Varon,2
Annie Buu
Hoï,1
Laurent
Gutmann,1,2,* and
Isabelle
Podglajen1,2
Service de Microbiologie, Hôpital
Broussais, 75674 Paris Cedex 14,1 and
L. R. M. A., Université Paris VI, 75270 Paris Cedex 06,2 France
Received 16 November 1999/Returned for modification 5 March
2000/Accepted 12 May 2000
Oropharyngeal samples from 60 hospitalized patients (30 fluoroquinolone [FQ]-treated and 30 non-FQ-treated patients) and 30 untreated nonhospitalized healthy control subjects yielded 20 isolates
of viridans group streptococci with reduced susceptibility to FQ,
mostly from the hospitalized patients. An efflux phenotype was commonly
encountered, expressed either alone or with topoisomerase mutations.
Interspecies transfer of the efflux phenotype was demonstrated via
transformation of Streptococcus pneumoniae R6 with DNA from S. mitis and S. oralis.
*
Corresponding author. Mailing address: L. R. M. A., Université Paris VI, 15, rue de l'Ecole de
Médecine, 75270 Paris Cedex 06, France. Phone:
33-1-42-34-68-63. Fax: 33-1-43-25-68-12. E-mail: gutmann{at}ccr.jussieu.fr.
Antimicrobial Agents and Chemotherapy, August 2000, p. 2197-2200, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
-
Ip, M., Chau, S. S. L., Chi, F., Tang, J., Chan, P. K.
(2007). Fluoroquinolone Resistance in Atypical Pneumococci and Oral Streptococci: Evidence of Horizontal Gene Transfer of Fluoroquinolone Resistance Determinants from Streptococcus pneumoniae. Antimicrob. Agents Chemother.
51: 2690-2700
[Abstract]
[Full Text]
-
Poole, K.
(2005). Efflux-mediated antimicrobial resistance. J Antimicrob Chemother
56: 20-51
[Abstract]
[Full Text]
-
Malhotra-Kumar, S., Lammens, C., Martel, A., Mallentjer, C., Chapelle, S., Verhoeven, J., Wijdooghe, M., Haesebrouck, F., Goossens, H.
(2004). Oropharyngeal carriage of macrolide-resistant viridans group streptococci: a prevalence study among healthy adults in Belgium. J Antimicrob Chemother
53: 271-276
[Abstract]
[Full Text]
-
Grohs, P., Houssaye, S., Aubert, A., Gutmann, L., Varon, E.
(2003). In Vitro Activities of Garenoxacin (BMS-284756) against Streptococcus pneumoniae, Viridans Group Streptococci, and Enterococcus faecalis Compared to Those of Six Other Quinolones. Antimicrob. Agents Chemother.
47: 3542-3547
[Abstract]
[Full Text]
-
Ruiz, J.
(2003). Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. J Antimicrob Chemother
51: 1109-1117
[Abstract]
[Full Text]
-
Jones, H. E., Brenwald, N. P., Owen, K. A., Gill, M. J.
(2003). A multidrug efflux phenotype mutant of Streptococcus pyogenes. J Antimicrob Chemother
51: 707-710
[Abstract]
[Full Text]
-
Hart, C A., Beeching, N. J
(2001). Prophylactic treatment of anthrax with antibiotics. BMJ
323: 1017-1018
[Full Text]
-
Bast, D. J., de Azavedo, J. C. S., Tam, T. Y., Kilburn, L., Duncan, C., Mandell, L. A., Davidson, R. J., Low, D. E.
(2001). Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae. Antimicrob. Agents Chemother.
45: 2631-2634
[Abstract]
[Full Text]