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Antimicrobial Agents and Chemotherapy, August 2000, p. 2211-2213, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparative Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Epidemiologically Defined Acinetobacter baumannii Strains

Barbara Heinemann,1 Hilmar Wisplinghoff,1 Michael Edmond,2 and Harald Seifert1,*

Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany,1 and Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia2

Received 16 March 2000/Returned for modification 25 April 2000/Accepted 11 May 2000

In vitro activities of seven fluoroquinolones against 140 clinical Acinetobacter baumannii isolates representing 138 different strain types were determined. The rank order of activity was clinafloxacin > gatifloxacin > levofloxacin > trovafloxacin > gemifloxacin = moxifloxacin > ciprofloxacin. The 31 outbreak-related A. baumannii strains were significantly more resistant than were 109 sporadic strains.

* Corresponding author. Mailing address: Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, Germany. Phone: 0049 221 4783009. Fax: 0049 221 4783067. E-mail: harald.seifert{at}uni-koeln.de.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2211-2213, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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