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Antimicrobial Agents and Chemotherapy, August 2000, p. 2214-2216, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Regional Differences in Metronidazole Resistance and Increasing Clarithromycin Resistance among Helicobacter pylori Isolates from Japan

Mototsugu Kato,1 Yoshio Yamaoka,2,3 Jae J. Kim,2,dagger Rita Reddy,2 Masahiro Asaka,4 Kei Kashima,3 Michael S. Osato,2 Fouad A. K. El-Zaatari,2 David Y. Graham,2 and Dong H. Kwon2,*

Department of Endoscopy1 and Third Department of Internal Medicine,4 Hokkaido University School of Medicine, Sapporo, and Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto,3 Japan, and Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, Texas2

Received 20 January 2000/Returned for modification 10 May 2000/Accepted 18 May 2000

The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).

* Corresponding author. Mailing address: Rm. 3A-320 (111D), Veterans Affairs Medical Center, 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7276. Fax: (713) 795-4471. E-mail: dkwon{at}bcm.tmc.edu.

dagger Present address: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Antimicrobial Agents and Chemotherapy, August 2000, p. 2214-2216, Vol. 44, No. 8
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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