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Antimicrobial Agents and Chemotherapy, September 2000, p. 2503-2506, Vol. 44, No. 9
Departments of
Pathobiology1 and
Medicine,2 University of Washington,
Seattle, Washington 98195
Received 28 December 1999/Returned for modification 28 March
2000/Accepted 1 June 2000
The mef gene, originally described for gram-positive
organisms and coding for an efflux pump, has been identified in
clinical isolates of Acinetobacter junii and
Neisseria gonorrhoeae. These strains could transfer the
mef gene at frequencies ranging from 10
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Copyright © 2000, American Society for Microbiology. All rights reserved.
Identification of the Conjugative mef
Gene in Clinical Acinetobacter junii and Neisseria
gonorrhoeae Isolates
6 to
10
9 into one or more of the following recipients:
gram-negative Moraxella catarrhalis, Neisseria
perflava/sicca and Neisseria mucosa and gram-positive
Enterococcus faecalis. Three Streptococcus
pneumoniae strains could transfer the mef gene into
Eikenella corrodens, Haemophilus influenzae,
Kingella denitrificans, M. catarrhalis, Neisseria meningitidis, N. perflava/sicca, and
N. mucosa at similar frequencies. The mef gene
can thus be transferred to and expressed in a variety of gram-negative recipients.
*
Corresponding author. Mailing address: Department of
Pathobiology, Box 357238, School of Public Health and Community
Medicine, University of Washington, Seattle, WA 98195-7238. Phone:
(206) 543-8001. Fax: (206) 543-3873. E-mail:
marilynr{at}u.washington.edu.
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