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Antimicrobial Agents and Chemotherapy, September 2000, p. 2518-2520, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of a New Ketolide, ABT-773, Alone and in Combination with Amoxicillin, Metronidazole, or Tetracycline against Helicobacter pylori

Susan L. Pendland,* Jennifer L. Prause, Melinda M. Neuhauser, Nicole Boyea, Jodi M. Hackleman, and Larry H. Danziger

Microbiology Research Laboratory, Department of Pharmacy Practice, The University of Illinois at Chicago, Chicago, Illinois

Received 22 November 1999/Returned for modification 19 March 2000/Accepted 26 May 2000

The in vitro activity of ABT-773, a new ketolide, was compared with those of clarithromycin, amoxicillin, metronidazole, and tetracycline against 15 strains of Helicobacter pylori. The MIC of ABT-773 at which 90% of isolates were inhibited was 0.25 µg/ml, which was 3 dilutions higher than that of the most active agent, clarithromycin. Synergy and antagonism were not seen with any combinations. Additive activity was seen with tetracycline, metronidazole, and amoxicillin in 100, 60, and 40% of the combinations, respectively.

* Corresponding author. Mailing address: The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood St., Chicago, IL 60612. Phone: (312) 996-8639. Fax: (312) 413-1797. E-mail: pendland{at}uic.edu.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2518-2520, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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